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Tumor necrosis factor-alpha dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies.

R C Benyon, E Y Bissonnette and A D Befus
J Immunol October 1, 1991, 147 (7) 2253-2258;
R C Benyon
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E Y Bissonnette
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A D Befus
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Abstract

Mast cells dispersed from human skin and purified by density-gradient centrifugation were cytotoxic toward the mouse fibrosarcoma cell line WEHI-164. Skin mast cells were not cytotoxic toward the NK cell-sensitive cell line K562. Killing of WEHI-164 occurred over a prolonged (greater than 18 h) period of incubation with mast cells and was effectively inhibited by polyclonal antibodies and mAb against TNF-alpha suggesting that this cytokine plays an important role in mast cell-mediated cytotoxicity. Whereas lysates of rat peritoneal mast cells exhibited cytotoxicity toward WEHI-164, this was not found with lysates of unstimulated skin mast cells suggesting that TNF-alpha is not stored preformed in the latter. Killing of WEHI-164 cells by skin mast cells was enhanced by anti-IgE and there was a significant correlation between histamine release and cytotoxicity after activation with this stimulus. We conclude that human skin mast cells are a potential source of TNF-alpha and suggest that these cells, particularly after activation, might contribute to the synthesis of this multifunctional cytokine in inflammatory sites.

  • Copyright © 1991 by American Association of Immunologists

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The Journal of Immunology
Vol. 147, Issue 7
1 Oct 1991
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Tumor necrosis factor-alpha dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies.
R C Benyon, E Y Bissonnette, A D Befus
The Journal of Immunology October 1, 1991, 147 (7) 2253-2258;

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Tumor necrosis factor-alpha dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies.
R C Benyon, E Y Bissonnette, A D Befus
The Journal of Immunology October 1, 1991, 147 (7) 2253-2258;
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Print ISSN 0022-1767        Online ISSN 1550-6606