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Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.

C S Subauste, A H Koniaris and J S Remington
J Immunol December 1, 1991, 147 (11) 3955-3959;
C S Subauste
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A H Koniaris
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J S Remington
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Abstract

Studies were performed to determine whether CTL against Toxoplasma gondii-infected cells could be induced in a murine model of T. gondii infection in which CD8+ T lymphocytes have been shown to play a major role in resistance against this parasite. In 51Cr release assays, nylon wool nonadherent spleen cells from BALB/c (H-2d) mice immunized with the temperature-sensitive (ts-4) mutant strain of T. gondii were cytotoxic for T. gondii-infected P815 (H-2d) mastocytoma cells but not for uninfected cells. This cytotoxic activity was remarkably increased after in vitro stimulation with T. gondii-infected syngeneic spleen cells. The effector cells were shown to be CD8+ T lymphocytes, because the cytotoxicity was significantly inhibited by depletion of CD8+ T lymphocytes but not by depletion of CD4+ T lymphocytes. This cytotoxic activity was genetically restricted. Spleen cells from T. gondii-immune BALB/c mice were not cytotoxic for T. gondii-infected EL4 (H-2b) thymoma cells, whereas spleen cells from T. gondii-immune C57B1/6 (H-2b) mice were cytotoxic for T. gondii-infected EL4 cells but not for T. gondii-infected P815 cells. The cytolytic activity of CD8+ T lymphocytes against T. gondii-infected cells might be a mechanism whereby these cells confer resistance against T. gondii.

  • Copyright © 1991 by American Association of Immunologists
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The Journal of Immunology
Vol. 147, Issue 11
1 Dec 1991
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Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.
C S Subauste, A H Koniaris, J S Remington
The Journal of Immunology December 1, 1991, 147 (11) 3955-3959;

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Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.
C S Subauste, A H Koniaris, J S Remington
The Journal of Immunology December 1, 1991, 147 (11) 3955-3959;
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Print ISSN 0022-1767        Online ISSN 1550-6606