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Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.

T Kamradt, P D Soloway, D L Perkins and M L Gefter
J Immunol November 15, 1991, 147 (10) 3296-3302;
T Kamradt
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P D Soloway
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D L Perkins
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M L Gefter
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Abstract

In a murine model of T cell-mediated autoimmune disease, experimental autoimmune encephalitis (EAE), 80% of all encephalitogenic T cell clones in H-2u mice use the V beta 8.2 TCR element. To induce EAE in susceptible strains of mice either heat-killed Bordetella pertussis organisms or Bordetella pertussis toxin (PT) must be injected in addition to Ag in CFA. We investigated the mechanisms by which PT facilitates the induction of EAE. Our data show, that PT interferes with the induction of Ag-induced peripheral T cell anergy. Furthermore it has a specific adjuvanticity for the autoantigen pAc1-11 in vivo and acts as a selective mitogen in vitro. We also tested the hypothesis that PT is a bacterial superantigen that specifically expands the V beta 8.2+ subset of T cells, thereby expanding the encephalitogenic T cell clones that are contained in this subset, so that the number of autoreactive T cells is brought over a critical threshold, necessary to induce autoimmune disease. Our data show that PT is not a superantigen. Staphylococcal enterotoxin B, a V beta 8.2-specific superantigen, does not enhance the immune response to the encephalitogenic peptide.

  • Copyright © 1991 by American Association of Immunologists
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The Journal of Immunology
Vol. 147, Issue 10
15 Nov 1991
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Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.
T Kamradt, P D Soloway, D L Perkins, M L Gefter
The Journal of Immunology November 15, 1991, 147 (10) 3296-3302;

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Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.
T Kamradt, P D Soloway, D L Perkins, M L Gefter
The Journal of Immunology November 15, 1991, 147 (10) 3296-3302;
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Print ISSN 0022-1767        Online ISSN 1550-6606