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IFN-gamma retards the turnover of H-2Dd antigens by splenic lymphocytes.

A Guha and R E Cone
J Immunol March 15, 1991, 146 (6) 1858-1861;
A Guha
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R E Cone
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Abstract

The effect of IFN-gamma on the rate of shedding and biosynthesis of H-2Dd was determined by culture of cell surface-radioiodinated BALB/c spleen cells with rIFN-gamma or spleen cells metabolically labeled with 35S-methionine in the presence of IFN-gamma. Radioiodinated or 35S-labeled H-2Dd was quantitated by immunoprecipitation of H-2Dd from detergent lysates of radiolabeled cells taken at different culture intervals. The loss of 125I-labeled H-2Dd was retarded 75 to 90% by IFN-gamma whereas the biosynthetic rate was unaffected during the first 10-h culture. The net result was a ninefold increase in newly synthesized cell-associated H-2Dd. The results were consistent with determination of the kinetics of increased expression of H-2Dd determined by immunofluorescence and suggest that an early effect of IFN-gamma on the expression of class I Ag is a retardation of catabolism leading to an increase of newly synthesized class I Ag.

  • Copyright © 1991 by American Association of Immunologists

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The Journal of Immunology
Vol. 146, Issue 6
15 Mar 1991
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IFN-gamma retards the turnover of H-2Dd antigens by splenic lymphocytes.
A Guha, R E Cone
The Journal of Immunology March 15, 1991, 146 (6) 1858-1861;

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IFN-gamma retards the turnover of H-2Dd antigens by splenic lymphocytes.
A Guha, R E Cone
The Journal of Immunology March 15, 1991, 146 (6) 1858-1861;
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Print ISSN 0022-1767        Online ISSN 1550-6606