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Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.

B Endler-Jobst, B Schraven, B Hutmacher and S C Meuer
J Immunol March 15, 1991, 146 (6) 1736-1742;
B Endler-Jobst
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B Schraven
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B Hutmacher
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S C Meuer
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Abstract

We investigated the involvement of IL-1 and IL-6 in activation of resting human T lymphocytes via the Ti-Ag receptor/CD3-dependent and the CD2-dependent pathways, respectively. When lymphocytes were triggered through CD3-Ti, neither IL-1 nor IL-6 nor the combination of both cytokines was capable of inducing a proliferative response, whereas addition of monocytes or IL-2 to such a system mediated DNA synthesis and cellular mitosis. In contrast, in the presence of submitogenic concentrations of mAb directed at CD2, IL-1 and/or IL-6 produced marked comitogenic dose-dependent effects. Moreover, although the action of IL-1 was clearly dependent on expression of the IL-2/IL-2R system, proliferation to CD2 antibody plus IL-6 could not be blocked by mAb directed at the IL-2R and/or IL-4. T cell responsiveness to both IL-1 and IL-6 was facilitated in the presence of CD58-like signals as delivered by human rCD58, SRBC or a mAb (anti-T111A), which binds to an interaction site for CD58 on the human CD2 molecule. These findings indicate that CD2 and its ligand CD58 play an important role in T cell/monocyte interactions during primary immune responses by means of upregulating T cell susceptibility to monocyte-derived cytokines.

  • Copyright © 1991 by American Association of Immunologists

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The Journal of Immunology
Vol. 146, Issue 6
15 Mar 1991
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Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.
B Endler-Jobst, B Schraven, B Hutmacher, S C Meuer
The Journal of Immunology March 15, 1991, 146 (6) 1736-1742;

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Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.
B Endler-Jobst, B Schraven, B Hutmacher, S C Meuer
The Journal of Immunology March 15, 1991, 146 (6) 1736-1742;
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Print ISSN 0022-1767        Online ISSN 1550-6606