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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

D F Fiorentino, A Zlotnik, P Vieira, T R Mosmann, M Howard, K W Moore and A O'Garra
J Immunol May 15, 1991, 146 (10) 3444-3451;
D F Fiorentino
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A Zlotnik
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P Vieira
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T R Mosmann
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M Howard
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K W Moore
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A O'Garra
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Abstract

Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of APC. By preincubating APC with IL-10, we demonstrate that IL-10 acts principally on APC to inhibit IFN-gamma production by Th1 clones. Moreover, IL-10 is not active when Th1 cells are stimulated with glutaraldehyde-fixed APC, which also indicates that its action involves regulation of APC function. Furthermore, IL-10 inhibits cytokine synthesis by Th1 cells stimulated with the super-antigen Staphylococcus enterotoxin B, which does not appear to require processing. Flow microfluorimetry purified splenic or peritoneal B cells and macrophages, and B cell and macrophage cell lines can present Ag to Th1 clones. However, IL-10 acts only on sorted macrophages and the macrophage cell line to suppress IFN-gamma production by Th1 clones. IL-10 does not show this effect when B cells are used as APC. In contrast, IL-10 does not impair the ability of APC to stimulate cytokine production by Th2 cells. IL-10 does not decrease IFN-gamma-induced I-Ad levels on a macrophage cell line. Inasmuch as IL-10 also inhibits IL-2-induced IFN-gamma production by Th1 cells in an Ag-free system requiring only the presence of accessory cells, these data suggest that IL-10 may inhibit macrophage accessory cell function which is independent of TCR-class II MHC interactions.

  • Copyright © 1991 by American Association of Immunologists

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The Journal of Immunology
Vol. 146, Issue 10
15 May 1991
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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
D F Fiorentino, A Zlotnik, P Vieira, T R Mosmann, M Howard, K W Moore, A O'Garra
The Journal of Immunology May 15, 1991, 146 (10) 3444-3451;

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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
D F Fiorentino, A Zlotnik, P Vieira, T R Mosmann, M Howard, K W Moore, A O'Garra
The Journal of Immunology May 15, 1991, 146 (10) 3444-3451;
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Print ISSN 0022-1767        Online ISSN 1550-6606