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BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential.

L Ramakrishnan, Q Wu, A Yue, M D Cooper and N Rosenberg
J Immunol September 1, 1990, 145 (5) 1603-1608;
L Ramakrishnan
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Q Wu
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A Yue
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M D Cooper
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N Rosenberg
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Abstract

BP-1 antibody recognizes a cell surface molecule related to the zinc-dependent metallopeptidases that is expressed during a narrow window early in B cell differentiation. Expression of the same molecule, as originally recognized by the mAb 6C3, is widely accepted to be associated with the complete malignant transformation of pre-B lymphoid cells. We have examined BP-1/6C3 expression in a panel of established Abelson virus-transformed cells that includes both cells analogous to pre-B cells and to less differentiated B lineage cells that have not yet completed Ig H chain gene rearrangement. This analysis reveals that many of the less differentiated transformants do not express BP-1/6C3 for an extended culture period. In contrast, virtually all transformants that are analogous to normal pre-B cells express the determinant early in their culture history. The BP-1/6C3 negative transformants are fully tumorigenic in syngeneic mice, demonstrating that BP-1/6C3 expression is not required for complete malignant transformation. Our data thus suggest that the pattern of BP-1/6C3 expression in Abelson virus-transformed cells mimics that observed in normal cells and is indicative of a differentiation event unrelated to the malignant potential of the cells.

  • Copyright © 1990 by American Association of Immunologists

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The Journal of Immunology
Vol. 145, Issue 5
1 Sep 1990
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BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential.
L Ramakrishnan, Q Wu, A Yue, M D Cooper, N Rosenberg
The Journal of Immunology September 1, 1990, 145 (5) 1603-1608;

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BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential.
L Ramakrishnan, Q Wu, A Yue, M D Cooper, N Rosenberg
The Journal of Immunology September 1, 1990, 145 (5) 1603-1608;
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Print ISSN 0022-1767        Online ISSN 1550-6606