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Activation of C3H/HeJ macrophage tumoricidal activity and cytokine release by R-chemotype lipopolysaccharide preparations. Differential effects of IFN-gamma.

L M Flebbe, S K Chapes and D C Morrison
J Immunol September 1, 1990, 145 (5) 1505-1511;
L M Flebbe
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S K Chapes
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D C Morrison
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Abstract

We have investigated the relative immunostimulatory activities of S-chemotype LPS and R-chemotype LPS preparations on C3H/HeJ peritoneal macrophages in vitro. As assessed by either secretion of TNF-alpha or IL-1, some of the R-chemotype LPS manifest significant activity on these normally LPS-unresponsive cells. The expression of IL-1 activity by R-LPS-stimulated C3H/HeJ macrophages was unaffected by IFN-gamma; however, this cytokine significantly enhanced TNF-alpha production by the same cells. The R-chemotype LPS preparations alone were not able to activate C3H/HeJ macrophages to become tumoricidal but activity could readily be demonstrated in the presence of IFN-gamma. Of potential importance is the observation that the profile of relative activity of the various R-chemotype LPS preparations for macrophage activation does not parallel that previously obtained by us for the C3H/HeJ B-lymphocyte activation.

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The Journal of Immunology
Vol. 145, Issue 5
1 Sep 1990
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Activation of C3H/HeJ macrophage tumoricidal activity and cytokine release by R-chemotype lipopolysaccharide preparations. Differential effects of IFN-gamma.
L M Flebbe, S K Chapes, D C Morrison
The Journal of Immunology September 1, 1990, 145 (5) 1505-1511;

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Activation of C3H/HeJ macrophage tumoricidal activity and cytokine release by R-chemotype lipopolysaccharide preparations. Differential effects of IFN-gamma.
L M Flebbe, S K Chapes, D C Morrison
The Journal of Immunology September 1, 1990, 145 (5) 1505-1511;
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Print ISSN 0022-1767        Online ISSN 1550-6606