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HIV-1 transmission and function of virus-infected monocytes/macrophages.

D L Mann, S Gartner, F Le Sane, H Buchow and M Popovic
J Immunol March 15, 1990, 144 (6) 2152-2158;
D L Mann
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S Gartner
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F Le Sane
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H Buchow
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M Popovic
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Abstract

Monocyte/macrophages (MM) were isolated from HIV-1 seronegative individuals, infected with HIV-1 and examined for their ability to infect autologous T lymphocytes with and without concomitant presentation of exogenous Ag. HIV-1-infected MM presented tetanus toxin (TT) and streptokinase to T cells (as measured by [3H]thymidine incorporation) comparable to presentation by uninfected MM. In these studies, it was observed that HIV-1-infected MM without additional exogenous Ag stimulated autologous T lymphocytes, however, to a lesser degree than with TT and streptokinase. Virus production in T cells appeared to be relative to the degree of stimulation with the highest levels of stimulation and infection observed when T cells were exposed to HIV-1-infected TT-presenting MM. Studies were carried out to examine some of the restricting elements in MM-mediated infection of T lymphocytes with and without TT presentation. Antibodies to CD4, as well as soluble immunopurified gp120, blocked cell-mediated infection indicating that infection of T cells was through the CD4 molecule as has been demonstrated with cell-free virus. In addition, soluble gp120 inhibited Ag presentation by HIV-1-infected and uninfected MM. mAb to MHC class II Ag HLA-DR and -DP blocked T cell infection by HIV-1-infected MM with and without presentation of TT. No effect was observed with mAb to MHC class I Ag. These results indicate that virus transmission to T lymphocytes can be mediated by HIV-1-infected MM and that these cells maintain their function as APC. Activation of T cells appears to be important in the process of T cell infection in this system inasmuch as antibodies that block Ag presentation and thus a T cell proliferative signal inhibit infection.

  • Copyright © 1990 by American Association of Immunologists

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The Journal of Immunology
Vol. 144, Issue 6
15 Mar 1990
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HIV-1 transmission and function of virus-infected monocytes/macrophages.
D L Mann, S Gartner, F Le Sane, H Buchow, M Popovic
The Journal of Immunology March 15, 1990, 144 (6) 2152-2158;

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HIV-1 transmission and function of virus-infected monocytes/macrophages.
D L Mann, S Gartner, F Le Sane, H Buchow, M Popovic
The Journal of Immunology March 15, 1990, 144 (6) 2152-2158;
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Print ISSN 0022-1767        Online ISSN 1550-6606