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CD44 contributes to T cell activation.

S Huet, H Groux, B Caillou, H Valentin, A M Prieur and A Bernard
J Immunol August 1, 1989, 143 (3) 798-801;
S Huet
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H Groux
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B Caillou
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H Valentin
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A M Prieur
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A Bernard
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Abstract

We demonstrate here that the CD44 molecule, which mediates lymphocyte adhesion to high endothelial venules (HEV), is also involved in the delivery of an activation signal to the T cell. We have produced a CD44 mAb (H90) which is able to block the binding of lymphocytes to high endothelial venules. H90 had no effect on [3H]TdR incorporation of whole PBL stimulated by lectins, allogeneic cells, or CD3 mAb in the soluble phase; in contrast, it strongly increased [3H]TdR incorporation of PBL stimulated by CD2 pairs of mAb or by CD3 mAb linked to the plastic culture plates, when purified T cells were used, H90 mAb could efficiently induce them to proliferate after a primary signal of activation delivered via cross-linked CD3 or via CD2, an effect mediated by Il-2 synthesis and Il-2R expression. Thus, the effect of H90 mAb resembles the mitogenic effect of CD28 "9.3" mAb. However, several results show that CD28 and CD44 mediate different signals to the T cells: i) in contrast to CD28 mAb, CD44 mAb cannot complement the signal delivered by a soluble CD3 mAb, lectins, or PMA; ii) CD44 mAb, at the difference of CD28 mAb, cannot induce CD3+ thymocytes to proliferate in conjunction with a first signal provided via cross-linked CD3 or via CD2; iii) F(ab) fragments of H90 were efficient, whereas divalent fragments of CD29 9.3 mAb are required to produce activation signals; and iv) CD44 and CD28 mAb produce a very strong synergistic effect on T cell proliferation. These results fit with previous ones showing that endothelial cells can play the role of accessory cell in T cell activation and that a hierarchy of signaling can be delivered to T cells via CD3 and CD2.

  • Copyright © 1989 by American Association of Immunologists

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The Journal of Immunology
Vol. 143, Issue 3
1 Aug 1989
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CD44 contributes to T cell activation.
S Huet, H Groux, B Caillou, H Valentin, A M Prieur, A Bernard
The Journal of Immunology August 1, 1989, 143 (3) 798-801;

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CD44 contributes to T cell activation.
S Huet, H Groux, B Caillou, H Valentin, A M Prieur, A Bernard
The Journal of Immunology August 1, 1989, 143 (3) 798-801;
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Print ISSN 0022-1767        Online ISSN 1550-6606