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Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.

D A Chow and R D Bennet
J Immunol May 15, 1989, 142 (10) 3702-3706;
D A Chow
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R D Bennet
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Abstract

Evidence from correlative studies and Winn-type assays in syngeneic murine models has suggested that natural antibodies contribute to resistance against tumors in vivo. The B cell deficit associated with the X-linked immunodeficiency of CBA/N strain mice provided a genetic model in which to further test this question. RI-28, a radiation-induced T cell leukemia of the CBA/H strain acquired reduced levels of fluorescence-detected natural antibodies from the serum of X-linked immunodeficiency-bearing CBA/N and male (CBA/N x CBA/J) F1 mice compared with the serum from normals. Threshold s.c. inocula of the RI-28 appeared sooner and produced higher tumor frequencies in the X-linked immunodeficiency-bearing animals. This data coupled with the lack of correlating deficiencies in natural killer cell or activated macrophage activity provide the first genetic evidence for the hypothesis.

  • Copyright © 1989 by American Association of Immunologists

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The Journal of Immunology
Vol. 142, Issue 10
15 May 1989
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Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.
D A Chow, R D Bennet
The Journal of Immunology May 15, 1989, 142 (10) 3702-3706;

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Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.
D A Chow, R D Bennet
The Journal of Immunology May 15, 1989, 142 (10) 3702-3706;
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Print ISSN 0022-1767        Online ISSN 1550-6606