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T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.

C T Weaver, L M Duncan and E R Unanue
J Immunol May 15, 1989, 142 (10) 3469-3476;
C T Weaver
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L M Duncan
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E R Unanue
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Abstract

We described in a previous study two pathways by which Th cells induced macrophage membrane IL-1(mIL-1) during Ag presentation. One pathway was lymphokine-independent and mediated by cell-cell contact. The second was lymphokine-dependent. We have now characterized this lymphokine and show that it belongs to the TNF family of proteins. All TH1 and most TH2 clones produced the lymphokine, although TH1 levels were markedly greater. Both types of clones also induced macrophage mIL-1 by cell-cell contact (i.e., in the absence of lymphokine release). Examination of macrophages by in situ hybridization showed that both IL-1 alpha and IL-1 beta mRNA were coordinately induced during Ag presentation to either TH1 or TH2 clones.

  • Copyright © 1989 by American Association of Immunologists

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The Journal of Immunology
Vol. 142, Issue 10
15 May 1989
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T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.
C T Weaver, L M Duncan, E R Unanue
The Journal of Immunology May 15, 1989, 142 (10) 3469-3476;

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T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.
C T Weaver, L M Duncan, E R Unanue
The Journal of Immunology May 15, 1989, 142 (10) 3469-3476;
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Print ISSN 0022-1767        Online ISSN 1550-6606