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Induction of allergen-specific IgE and IgG responses by anti-idiotypic antibodies.

S Nagpal, K N Shanthi, R Kori, H Schroder, D D Metcalfe and P V Subba Rao
J Immunol May 15, 1989, 142 (10) 3411-3415;
S Nagpal
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K N Shanthi
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R Kori
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H Schroder
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D D Metcalfe
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P V Subba Rao
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Abstract

In order to explore idiotypic, anti-idiotypic, and anti-anti-idiotypic responses to allergens, BALB/c mice were immunized with affinity-purified human idiotypic antibodies directed against a highly purified shrimp allergen. This resulted in the production of anti-idiotypic antibodies which were quantitated by using rabbit idiotypic antibodies raised against the same purified allergen. The mouse anti-idiotypic antibodies recognized shrimp-specific human idiotypic antibodies of the IgE isotype from 18 of 20 individuals, and IgG antibodies from 14 of 20 shrimp-sensitive patients. Immunization of BALB/c mice with affinity-purified, allergen-specific anti-idiotypic antibodies induced anti-allergen IgE and IgG responses in the absence of the allergen. This paper thus presents evidence that anti-idiotypic antibodies raised against allergen-specific idiotypic antibodies may substitute for the original allergen in the induction of allergen-specific idiotypic antibodies. The demonstration of shared idiotopes on IgG and IgE antibodies in the sera of shrimp-sensitive patients supports the use of allergen-specific anti-idiotypic antibodies as surrogate allergens.

  • Copyright © 1989 by American Association of Immunologists

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The Journal of Immunology
Vol. 142, Issue 10
15 May 1989
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Induction of allergen-specific IgE and IgG responses by anti-idiotypic antibodies.
S Nagpal, K N Shanthi, R Kori, H Schroder, D D Metcalfe, P V Subba Rao
The Journal of Immunology May 15, 1989, 142 (10) 3411-3415;

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Induction of allergen-specific IgE and IgG responses by anti-idiotypic antibodies.
S Nagpal, K N Shanthi, R Kori, H Schroder, D D Metcalfe, P V Subba Rao
The Journal of Immunology May 15, 1989, 142 (10) 3411-3415;
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Print ISSN 0022-1767        Online ISSN 1550-6606