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In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.

J T Hom, A M Bendele and D G Carlson
J Immunol August 1, 1988, 141 (3) 834-841;
J T Hom
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A M Bendele
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D G Carlson
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Abstract

In an attempt to examine the in vivo proinflammatory properties of IL-1, the effects of rIL-1 beta on the development of collagen-induced arthritis in mice were investigated. The results presented in this paper demonstrated that the administration of rIL-1 beta via mini-osmotic pumps into DBA/1 mice which were suboptimally immunized with native chick type II collagen (NcII) markedly accelerated the onset as well as the progression of the arthritic disease. When IL-1-containing osmotic pumps were s.c. implanted onto mice 18 days post-collagen immunization, clinical signs of arthritis appeared within 3 to 4 days after the implant with the pumps. Maximal incidence of arthritis which was usually 80 to 100% occurred between the 6th and 7th day after the administration of rIL-1 beta. Histologic analyses revealed that the knee and ankle joints from mice which were treated with rIL-1 beta for 7 days were most severely and consistently affected. Furthermore, these IL-1-treated mice exhibited granulocytic hyperplasia within the marrow as well as marked peripheral blood neutrophilia. By contrast, arthritis was not observed during the 7-day course of the IL-1 study in the following control groups: 1) mice that were only immunized with NcII, and 2) collagen-immunized mice which received osmotic pumps containing PBS. A substantial number of these collagen-immunized mice which were not treated with IL-1 eventually developed arthritis but at later times after the incidence of arthritis had peaked in the IL-1-treated group. In addition, unimmunized mice failed to develop arthritis upon treatments with IL-1 beta. Moreover, the humoral responses to NcII were not altered in the IL-1-treated mice. Thus, these in vivo studies suggest that IL-1 is potentially capable of triggering the various inflammatory events of collagen-induced arthritis, and thereby, contribute to the pathogenesis of murine arthritis.

  • Copyright © 1988 by American Association of Immunologists

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The Journal of Immunology
Vol. 141, Issue 3
1 Aug 1988
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In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.
J T Hom, A M Bendele, D G Carlson
The Journal of Immunology August 1, 1988, 141 (3) 834-841;

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In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice.
J T Hom, A M Bendele, D G Carlson
The Journal of Immunology August 1, 1988, 141 (3) 834-841;
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Print ISSN 0022-1767        Online ISSN 1550-6606