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HIV-1-specific production of IFN-gamma and modulation by recombinant IL-2 during early HIV-1 infection.

C Rinaldo, P Piazza, Y Z Wang, J Armstrong, P Gupta, M Ho, S Petteway, D Reed, D Lyter and L Kingsley
J Immunol May 15, 1988, 140 (10) 3389-3393;
C Rinaldo
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P Piazza
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Y Z Wang
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J Armstrong
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P Gupta
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M Ho
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S Petteway
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D Reed
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D Lyter
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L Kingsley
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Abstract

Specific cellular immune responses to human immunodeficiency virus type 1 (HIV-1) were assessed in mononuclear leukocyte cultures from homosexual men with documented, early phase HIV-1 infection. Cell cultures from men with a mean duration of 1.3 yr (range, 0.3 to 2.2 yr) of HIV-1 infection were treated with UV-inactivated, whole, purified HIV-1 Ag together with various concentrations of rIL-2. Cell supernatants were harvested after 5-day incubation and assayed for IFN activity against encephalomyocarditis virus in human WISH cells. IFN subtypes were characterized by neutralization of antiviral activity with antiserum specific for human IFN-gamma and IFN-alpha. Results showed that cultures from 68% (17 of 25) of the HIV-1-seropositive subjects produced "immune" IFN-gamma in response to whole HIV-1 Ag plus rIL-2. IFN-gamma was induced in only 20% (5 of 25) of cultures treated with HIV-1 Ag alone. Enhancement of HIV-1-specific IFN-gamma production by rIL-2 was synergistic rather than additive in that titers induced by the mixture were consistently higher than the sum of IFN titers induced by HIV-1 or rIL-2 alone. This effect was not demonstrable in cultures from 18 HIV-1-seronegative men. Similarly, HIV-1-immune specific augmentation of IFN-gamma production by rIL-2 was noted for PENV9, a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment. Production of IFN-gamma may be an important, HIV-1-immune specific parameter in the host response to this retrovirus.

  • Copyright © 1988 by American Association of Immunologists

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The Journal of Immunology
Vol. 140, Issue 10
15 May 1988
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HIV-1-specific production of IFN-gamma and modulation by recombinant IL-2 during early HIV-1 infection.
C Rinaldo, P Piazza, Y Z Wang, J Armstrong, P Gupta, M Ho, S Petteway, D Reed, D Lyter, L Kingsley
The Journal of Immunology May 15, 1988, 140 (10) 3389-3393;

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HIV-1-specific production of IFN-gamma and modulation by recombinant IL-2 during early HIV-1 infection.
C Rinaldo, P Piazza, Y Z Wang, J Armstrong, P Gupta, M Ho, S Petteway, D Reed, D Lyter, L Kingsley
The Journal of Immunology May 15, 1988, 140 (10) 3389-3393;
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Print ISSN 0022-1767        Online ISSN 1550-6606