Summary
Histamine injected intravenously into normal dogs has the effect of delaying the normal parenteral denaturization of foreign protein. This is shown: (a) by a prolongation of the initial period of increased anaphylactic toxicity, and (b) by a marked delay in the development of complete anaphylactic detoxication.
Since histamine is known to inhibit the action of certain tissue enzymes, this finding is not inconsistent with the hypothesis that the initial increased toxicity and the subsequent complete detoxication of parentically introduced foreign proteins are due to enzyme action (2).
Footnotes
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↵1 Work aided by a grant from the Committee on Scientific Research of the American Medical Association.
- Received October 15, 1927.
- Copyright © 1927 by The American Association of Immunologists, Inc.
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