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Activated lymphocytes during acute Epstein-Barr virus infection.

B E Tomkinson, D K Wagner, D L Nelson and J L Sullivan
J Immunol December 1, 1987, 139 (11) 3802-3807;
B E Tomkinson
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D K Wagner
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D L Nelson
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J L Sullivan
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Abstract

Activated lymphocytes, as identified by HLA-DR expression, associated with acute Epstein-Barr virus (EBV)-induced infectious mononucleosis (IM) were shown to be a heterogeneous population containing significantly elevated cytotoxic/suppressor (CD8) T cells, natural killer (CD16) cells and helper (CD4) T cells. CD8 T cells were the primary activated population representing 24.5% of the total lymphocyte population. The activated CD4 T cells and natural killer cells accounted for 6.7% and 3.5% of the total lymphocyte population, respectively. Analysis of serum soluble interleukin 2 receptors (IL-2R) demonstrated significantly (p less than 0.001) elevated levels in the serum of acute IM patients compared with normal controls. Elevated levels of serum IL-2R were correlated (r = 0.67) with increased percentages of Leu 2a+/HLA-DR+T cells (i.e., activated CD8 T cells). Patients with X-linked lymphoproliferative syndrome and virus-associated hemophagocytic syndrome, two syndromes associated with severe acute EBV infections, demonstrated the most dramatic increase in serum IL-2R levels. These data demonstrate that EBV is associated with intense immune stimulation and that during acute IM activated lymphocytes, other than the CD8 T cells, may contribute to the immune response to EBV.

  • Copyright © 1987 by American Association of Immunologists

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The Journal of Immunology
Vol. 139, Issue 11
1 Dec 1987
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Activated lymphocytes during acute Epstein-Barr virus infection.
B E Tomkinson, D K Wagner, D L Nelson, J L Sullivan
The Journal of Immunology December 1, 1987, 139 (11) 3802-3807;

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Activated lymphocytes during acute Epstein-Barr virus infection.
B E Tomkinson, D K Wagner, D L Nelson, J L Sullivan
The Journal of Immunology December 1, 1987, 139 (11) 3802-3807;
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Print ISSN 0022-1767        Online ISSN 1550-6606