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Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks.

S Rojo, P Aparicio, J A Hansen, S Y Choo and J A López de Castro
J Immunol November 15, 1987, 139 (10) 3396-3401;
S Rojo
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P Aparicio
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J A Hansen
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S Y Choo
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J A López de Castro
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Abstract

The structure of a new functional variant B27d has been established by comparative peptide mapping and radiochemical sequencing. This analysis completes the structural characterization of the six known histocompatibility leukocyte antigen (HLA)-B27 subtypes. The only detected amino acid change between the main HLA-B27.1 subtype and B27d is that of Tyr59 to His59. Position 59 has not been previously found to vary among class I HLA or H-2 antigens. Such substitution accounts for the reported isoelectric focusing pattern of this variant. HLA-B27d is the only B27 variant found to differ from other subtypes by a single amino acid replacement. The nature of the change is compatible with its origin by a point mutation from HLA-B27.1. Because B27d was found only in American blacks and in no other ethnic groups, it is suggested that this variant originated as a result of a mutation of the B27.1 gene that occurred within the black population.

  • Copyright © 1987 by American Association of Immunologists

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The Journal of Immunology
Vol. 139, Issue 10
15 Nov 1987
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Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks.
S Rojo, P Aparicio, J A Hansen, S Y Choo, J A López de Castro
The Journal of Immunology November 15, 1987, 139 (10) 3396-3401;

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Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks.
S Rojo, P Aparicio, J A Hansen, S Y Choo, J A López de Castro
The Journal of Immunology November 15, 1987, 139 (10) 3396-3401;
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Print ISSN 0022-1767        Online ISSN 1550-6606