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Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. I. MHC-restricted activation of B cells by an IL 2-dependent pathway.

Y Asano, T Nakayama, M Kubo, K Nakanishi, R J Hodes and T Tada
J Immunol February 1, 1987, 138 (3) 667-673;
Y Asano
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T Nakayama
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M Kubo
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K Nakanishi
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R J Hodes
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T Tada
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Abstract

The present study was carried out to determine whether the MHC-restricted and MHC-unrestricted B cell activation pathways mediated by a single cloned Th cell are separable, and whether these two pathways are mediated by distinct mechanisms. It was demonstrated that the two B cell activating functions of a single cloned Th cell could be separated by their sensitivity to irradiation. It was shown that MHC-restricted B cell activation is mediated by a radiosensitive Th cell function, whereas MHC-unrestricted B cell activation is mediated by a radioresistant function of the same Th cell. In addition, it was shown that recombinant IL 2 can restore or replace the radiosensitive component of MHC-restricted cognate helper function.

  • Copyright © 1987 by American Association of Immunologists

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The Journal of Immunology
Vol. 138, Issue 3
1 Feb 1987
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Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. I. MHC-restricted activation of B cells by an IL 2-dependent pathway.
Y Asano, T Nakayama, M Kubo, K Nakanishi, R J Hodes, T Tada
The Journal of Immunology February 1, 1987, 138 (3) 667-673;

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Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. I. MHC-restricted activation of B cells by an IL 2-dependent pathway.
Y Asano, T Nakayama, M Kubo, K Nakanishi, R J Hodes, T Tada
The Journal of Immunology February 1, 1987, 138 (3) 667-673;
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Print ISSN 0022-1767        Online ISSN 1550-6606