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Transcriptional regulation of genes encoding the acute-phase proteins CRP, SAA, and C3.

G Goldberger, D H Bing, J D Sipe, M Rits and H R Colten
J Immunol June 1, 1987, 138 (11) 3967-3971;
G Goldberger
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D H Bing
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J D Sipe
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M Rits
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H R Colten
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Abstract

Inflammation or acute tissue injury results in a programmed change in the concentration of several plasma proteins. Among these proteins, two--C-reactive protein (CRP) and serum amyloid A protein (SAA)--increase up to 1000-fold after an acute-phase stimulus in humans and rabbits. To determine the mechanism for regulation of acute-phase gene expression, we examined changes in the rates of transcription and specific hepatic mRNA content for rabbit CRP, SAA, and some complement protein mRNA during an acute-phase response. Induction of a sterile inflammatory reaction with intramuscular injection of turpentine resulted in an increase in the hepatocellular content of CRP, SAA, C3, and factor B mRNA and the transcription of CRP, SAA, and C3 genes. These data suggest that the increase in CRP, SAA, and C3 serum concentrations observed during an acute-phase reaction is due to an increase in biosynthesis and is, at least in part, under transcriptional control.

  • Copyright © 1987 by American Association of Immunologists

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The Journal of Immunology
Vol. 138, Issue 11
1 Jun 1987
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Transcriptional regulation of genes encoding the acute-phase proteins CRP, SAA, and C3.
G Goldberger, D H Bing, J D Sipe, M Rits, H R Colten
The Journal of Immunology June 1, 1987, 138 (11) 3967-3971;

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Transcriptional regulation of genes encoding the acute-phase proteins CRP, SAA, and C3.
G Goldberger, D H Bing, J D Sipe, M Rits, H R Colten
The Journal of Immunology June 1, 1987, 138 (11) 3967-3971;
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Print ISSN 0022-1767        Online ISSN 1550-6606