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Reduced allorecognition of adenovirus-2 infected cells.

M Andersson, A McMichael and P A Peterson
J Immunol June 1, 1987, 138 (11) 3960-3966;
M Andersson
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A McMichael
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P A Peterson
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Abstract

The early region 3 of adenovirus 2 encodes the membrane glycoprotein E19. This protein specifically binds class I transplantation antigens of a variety of species. Concomitant with this interaction the intracellular transport of newly synthesized class I heavy chains is abrogated. At late stages of the virus infection this leads to a notable decrease in the cell surface expression of class I antigens. We have studied how infection with adenovirus 2 influences target cell recognition by alloreactive cytolytic T lymphocytes. We found that the E19 protein-induced reduction of the HLA-B7 cell surface expression led to a greatly reduced lysis of the infected cells. These findings support our hypothesis that the E19 protein has evolved to facilitate the in vivo replication of the virus by reducing the expression of HLA class I antigens.

  • Copyright © 1987 by American Association of Immunologists
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The Journal of Immunology
Vol. 138, Issue 11
1 Jun 1987
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Reduced allorecognition of adenovirus-2 infected cells.
M Andersson, A McMichael, P A Peterson
The Journal of Immunology June 1, 1987, 138 (11) 3960-3966;

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Reduced allorecognition of adenovirus-2 infected cells.
M Andersson, A McMichael, P A Peterson
The Journal of Immunology June 1, 1987, 138 (11) 3960-3966;
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Print ISSN 0022-1767        Online ISSN 1550-6606