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Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.

O Martínez-Maza, E Crabb, R T Mitsuyasu, J L Fahey and J V Giorgi
J Immunol June 1, 1987, 138 (11) 3720-3724;
O Martínez-Maza
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E Crabb
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R T Mitsuyasu
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J L Fahey
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J V Giorgi
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Abstract

The expression of phenotypic markers on B lymphocytes in patients with the acquired immune deficiency syndrome (AIDS), in human immunodeficiency virus (HIV) seropositive individuals, and in healthy seronegative donors was examined by two-color flow cytometry. Patients with AIDS and HIV-seropositive individuals showed an elevated percentage of B cells bearing an activation marker, the transferrin receptor, when compared with donors not infected with HIV. A decrease in the percentage of resting (Leu-8 positive) B cells was also seen in AIDS patients and HIV-seropositive individuals. An increased percentage of circulating, immature (CALLA-positive, CD10) B cells was seen in AIDS patients. These phenotypic changes were accompanied by an increased level of spontaneous IgG and IgM secretion, and increased cell size within the total B cell population and in some B cell subpopulations, in patients with AIDS and in HIV-seropositive people. These results demonstrate that phenotypic changes indicative of in vivo B cell activation and immaturity accompany the polyclonal production of Ig seen in HIV-infected individuals.

  • Copyright © 1987 by American Association of Immunologists

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The Journal of Immunology
Vol. 138, Issue 11
1 Jun 1987
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Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.
O Martínez-Maza, E Crabb, R T Mitsuyasu, J L Fahey, J V Giorgi
The Journal of Immunology June 1, 1987, 138 (11) 3720-3724;

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Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.
O Martínez-Maza, E Crabb, R T Mitsuyasu, J L Fahey, J V Giorgi
The Journal of Immunology June 1, 1987, 138 (11) 3720-3724;
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Print ISSN 0022-1767        Online ISSN 1550-6606