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The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.

A M Wan, P Ennis, P Parham and N Holmes
J Immunol December 1, 1986, 137 (11) 3671-3674;
A M Wan
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P Ennis
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P Parham
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N Holmes
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Abstract

All HLA-B locus molecules have either the Bw4 or Bw6 epitopes. In addition, the Bw4 epitope is found on HLA-Aw23, Aw24, and A32, and Bw6 is also found on HLA-Cw3. The structural basis for these determinants and the evolution of their distribution among products of the HLA-B locus has been a long standing puzzle. To identify residues that may be involved in these determinants, we have cloned a gene for A32 and sequenced the protein encoding exons. Comparison of the predicted protein sequence with other HLA-A,B,C sequences identified residues 79 through 83 of the alpha 1 domain as having a pattern of polymorphic substitution that correlates with the presence and absence of the Bw4 and Bw6 epitopes.

  • Copyright © 1986 by American Association of Immunologists

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The Journal of Immunology
Vol. 137, Issue 11
1 Dec 1986
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The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.
A M Wan, P Ennis, P Parham, N Holmes
The Journal of Immunology December 1, 1986, 137 (11) 3671-3674;

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The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.
A M Wan, P Ennis, P Parham, N Holmes
The Journal of Immunology December 1, 1986, 137 (11) 3671-3674;
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Print ISSN 0022-1767        Online ISSN 1550-6606