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The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene.

B S Schepart, H Takahashi, K M Cozad, R Murray, K Ozato, E Appella and J A Frelinger
J Immunol May 1, 1986, 136 (9) 3489-3495;
B S Schepart
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H Takahashi
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K M Cozad
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R Murray
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K Ozato
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E Appella
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J A Frelinger
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Abstract

We present the complete nucleotide sequence and the deduced amino acid sequence of the H-2Dp class I gene. This gene, which was cloned from a B10.P genomic DNA library, encodes and intact, functional H-2Dp molecule. Comparative analysis of the Dp sequence with other class I sequences reveals both similarities and differences. This analysis also shows that these genes exhibit D region-specific, locus-specific, as well as allele-specific sequences. The H-2Dp nucleotide sequence is greater than 90% homologous to the H-2Ld and H-2Db genes and only approximately 85% homologous to the H-2Dd gene. The K region and Qa region genes are less homologous. The 3' noncoding sequences appear to be region-specific. All of the previously described D region genes, Db, Ld, and Dd, possess the B2-SINE Alu-like repetitive sequence, as does Dp. Thus, this B2 repeat is a region-specific marker present in all D region genes studied so far. The additional polyadenylation site found in the H-2Dp gene starting at nucleotide 4671, which is homologous to non-D region sequences, as well as unique protein Dp coding sequences, make this gene an interesting model for studying the evolution of polymorphism and structure/function relationships in the class I gene family.

  • Copyright © 1986 by American Association of Immunologists

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The Journal of Immunology
Vol. 136, Issue 9
1 May 1986
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The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene.
B S Schepart, H Takahashi, K M Cozad, R Murray, K Ozato, E Appella, J A Frelinger
The Journal of Immunology May 1, 1986, 136 (9) 3489-3495;

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The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene.
B S Schepart, H Takahashi, K M Cozad, R Murray, K Ozato, E Appella, J A Frelinger
The Journal of Immunology May 1, 1986, 136 (9) 3489-3495;
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Print ISSN 0022-1767        Online ISSN 1550-6606