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Identification of histamine releasing factor(s) in the late phase of cutaneous IgE-mediated reactions.

J A Warner, M M Pienkowski, M Plaut, P S Norman and L M Lichtenstein
J Immunol April 1, 1986, 136 (7) 2583-2587;
J A Warner
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M M Pienkowski
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M Plaut
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P S Norman
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L M Lichtenstein
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Abstract

We have shown that fluids collected from antigen-challenged skin blisters during the late phase reaction cause the release of substantial amounts of histamine (means = 42%, n = 14) from human basophils in vitro. Control fluids collected either during the immediate phase or from an unchallenged blister released less than or equal to 10% histamine from both basophils and lung mast cells. Late phase blister fluids induced low levels of histamine release from human lung cells (means = 11%, n = 4) that were slightly but not significantly greater than levels induced by control blister fluids. The characteristics of basophil release were similar to IgE-mediated stimuli in dose dependence, calcium and temperature requirements, and kinetics. The IgE dependence of the late phase blister fluid was demonstrated by desensitization of the basophils to anti-IgE, which obviated the response to anti-IgE and blister fluid but did not affect a non-IgE-mediated stimulus. Removal of the cell surface IgE with lactic acid also abolished the response to both anti-IgE and late phase blister fluid. Incubation of the "stripped" cells with serum containing IgE myeloma restored the response to anti-IgE but failed to affect response to late phase blister fluid. The characteristics of release obtained with this factor closely resemble those of an IgE-dependent histamine releasing factor from cultured macrophages previously described by our group.

  • Copyright © 1986 by American Association of Immunologists

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The Journal of Immunology
Vol. 136, Issue 7
1 Apr 1986
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Identification of histamine releasing factor(s) in the late phase of cutaneous IgE-mediated reactions.
J A Warner, M M Pienkowski, M Plaut, P S Norman, L M Lichtenstein
The Journal of Immunology April 1, 1986, 136 (7) 2583-2587;

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Identification of histamine releasing factor(s) in the late phase of cutaneous IgE-mediated reactions.
J A Warner, M M Pienkowski, M Plaut, P S Norman, L M Lichtenstein
The Journal of Immunology April 1, 1986, 136 (7) 2583-2587;
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Print ISSN 0022-1767        Online ISSN 1550-6606