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Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigen-specific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury.

C J Kelly, R Korngold, R Mann, M Clayman, T Haverty and E G Neilson
J Immunol January 1, 1986, 136 (2) 526-531;
C J Kelly
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R Korngold
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R Mann
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M Clayman
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T Haverty
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E G Neilson
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Abstract

In this report, we have examined the effector T cell repertoire in the spontaneous interstitial nephritis of kdkd mice. Lymph node cells from nephritic kdkd mice are capable of transferring this disease into thymectomized, irradiated, and bone marrow-reconstituted CBA/Ca recipients. CBA/Ca mice do not spontaneously develop interstitial nephritis and are normally resistant to the adoptive transfer of nephritic cells, a resistance that in the short term can be attenuated with low-dose cyclophosphamide. We therefore used delayed-type hypersensitivity responses and direct transfer of immune cells under the renal capsule to characterize nephritogenic effector cells from kdkd donor mice. Lyt-2+, L3T4- T cells from the peripheral lymphoid organs of nephritic kdkd mice, after adoptive transfer into cyclophosphamide-pretreated CBA/Ca recipients, mediate an antigen-specific delayed-type hypersensitivity response to renal tubular basement membrane antigens. These cells are restricted by gene products in H-2Kk; they are also present in nephritic, but not in control kidneys. We have also observed this same phenotypic subpopulation of kdkd lymphocytes mediate a destructive interstitial renal lesion within 7 days of being placed under the kidney capsule of CBA/Ca mice. These findings suggest that T lymphocytes reactive to a parenchymal tubular antigen are of substantial importance in the development of spontaneous interstitial nephritis in kdkd mice.

  • Copyright © 1986 by American Association of Immunologists
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The Journal of Immunology
Vol. 136, Issue 2
1 Jan 1986
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Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigen-specific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury.
C J Kelly, R Korngold, R Mann, M Clayman, T Haverty, E G Neilson
The Journal of Immunology January 1, 1986, 136 (2) 526-531;

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Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigen-specific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury.
C J Kelly, R Korngold, R Mann, M Clayman, T Haverty, E G Neilson
The Journal of Immunology January 1, 1986, 136 (2) 526-531;
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Print ISSN 0022-1767        Online ISSN 1550-6606