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Demonstration of NK cell-mediated lysis of varicella-zoster virus (VZV)-infected cells: characterization of the effector cells.

A B Tilden, R Cauda, C E Grossi, C M Balch, A D Lakeman and R J Whitley
J Immunol June 1, 1986, 136 (11) 4243-4248;
A B Tilden
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R Cauda
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C E Grossi
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C M Balch
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A D Lakeman
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R J Whitley
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Abstract

Infection with varicella-zoster virus (VZV) rendered RAJI cells more susceptible to lysis by non-adherent blood lymphocytes. At an effector to target ratio of 80:1 the mean percentage of 51Cr release of VZV-infected RAJI cells was 41 +/- 12%, whereas that of uninfected RAJI cells was 15 +/- 6%. The increased susceptibility to lysis was associated with increased effector to target conjugate formation in immunofluorescence binding assays. The effector cells cytotoxic for VZV-infected RAJI cells were predominantly Leu-11a+ Leu-4- granular lymphocytes as demonstrated by fluorescence-activated cell sorting. The effector cell active against VZV-infected RAJI cells appeared similar to those active against herpes simplex virus (HSV)-infected cells, because in cold target competition experiments the lysis of 51Cr-labeled VZV-infected RAJI cells was efficiently inhibited by either unlabeled VZV-infected RAJI cells (mean 71% inhibition, 2:1 ratio unlabeled to labeled target) or HSV-infected RAJI cells (mean 69% inhibition) but not by uninfected RAJI cells (mean 10% inhibition). In contrast, competition experiments revealed donor heterogeneity in the overlap between effector cells for VZV- or HSV-infected RAJI vs K-562 cells.

  • Copyright © 1986 by American Association of Immunologists

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The Journal of Immunology
Vol. 136, Issue 11
1 Jun 1986
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Demonstration of NK cell-mediated lysis of varicella-zoster virus (VZV)-infected cells: characterization of the effector cells.
A B Tilden, R Cauda, C E Grossi, C M Balch, A D Lakeman, R J Whitley
The Journal of Immunology June 1, 1986, 136 (11) 4243-4248;

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Demonstration of NK cell-mediated lysis of varicella-zoster virus (VZV)-infected cells: characterization of the effector cells.
A B Tilden, R Cauda, C E Grossi, C M Balch, A D Lakeman, R J Whitley
The Journal of Immunology June 1, 1986, 136 (11) 4243-4248;
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Print ISSN 0022-1767        Online ISSN 1550-6606