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Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines.

C A Nacy, A H Fortier, M S Meltzer, N A Buchmeier and R D Schreiber
J Immunol November 1, 1985, 135 (5) 3505-3511;
C A Nacy
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A H Fortier
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M S Meltzer
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N A Buchmeier
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R D Schreiber
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Abstract

Macrophages treated with lymphokine (LK)-rich culture fluids from antigen- or mitogen-stimulated spleen cells or the hybridoma T cell 24/G1, or murine recombinant interferon-gamma (IFN-gamma) from either transfected monkey kidney cells (cos rIFN-gamma) or bacterial (E. coli) DNA (rIFN-gamma) developed the capacity to kill intracellular amastigotes of Leishmania major. Removal of IFN activity from LK by neutralizing fluid phase monoclonal anti-rIFN-gamma antibody, or by solid phase immunoadsorption, left residual macrophage activation factors that induced approximately 50% of the macrophage anti-leishmanial activity of untreated LK. In contrast, rIFN-gamma subjected to the same antibody treatments lost all capacity to induce this macrophage effector function. These results suggest that the intracellular destruction of amastigotes is regulated by several different factors. One of these factors is clearly IFN-gamma, which is pleiotropic in its effects on macrophage functions. The other non-IFN LK factors are immunochemically unrelated to IFN-gamma, and may regulate macrophage microbicidal activities in a more selective manner.

  • Copyright © 1985 by American Association of Immunologists
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The Journal of Immunology
Vol. 135, Issue 5
1 Nov 1985
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Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines.
C A Nacy, A H Fortier, M S Meltzer, N A Buchmeier, R D Schreiber
The Journal of Immunology November 1, 1985, 135 (5) 3505-3511;

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Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines.
C A Nacy, A H Fortier, M S Meltzer, N A Buchmeier, R D Schreiber
The Journal of Immunology November 1, 1985, 135 (5) 3505-3511;
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Print ISSN 0022-1767        Online ISSN 1550-6606