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Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.

H T Petrie, L W Klassen and H D Kay
J Immunol January 1, 1985, 134 (1) 230-234;
H T Petrie
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L W Klassen
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H D Kay
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Abstract

Peripheral blood granulocytes from normal healthy donors were found to reproducibly inhibit the cytolytic effector function of specifically sensitized cytotoxic T lymphocytes in vitro when co-incubated with these effector cells and target cells in 8 hr 51Cr release assays. Inhibition required intact granulocytes, was proportional to the number of granulocytes present, and was independent of granulocyte adherence, phagocytic function, and viability. Equivalent numbers of enriched normal or leukemic peripheral T lymphocytes did not cause inhibition of 51Cr release, and preincubation of granulocytes with effectors did not significantly alter viability or cytotoxic function. Because granulocytes can inhibit natural killer cell function in vitro, these data indicate that granulocytes can regulate diverse antigen-specific and spontaneous cytotoxic functions in vitro, suggesting that circulating granulocytes may have the potential for in vivo regulation of these cytotoxic effectors.

  • Copyright © 1985 by American Association of Immunologists

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The Journal of Immunology
Vol. 134, Issue 1
1 Jan 1985
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Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.
H T Petrie, L W Klassen, H D Kay
The Journal of Immunology January 1, 1985, 134 (1) 230-234;

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Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes.
H T Petrie, L W Klassen, H D Kay
The Journal of Immunology January 1, 1985, 134 (1) 230-234;
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Print ISSN 0022-1767        Online ISSN 1550-6606