Summary and Conclusions
Urinary bladders of goat serum immune dogs, therefore, show no suggestion of an acquired insusceptibility to the histamine-like substances explosively formed or liberated by the hypersensitive liver during the initial stages of horse serum shock. Horse serum immune bladders show no suggestion of an acquired insusceptibility to the hepatic anaphylatoxins of goat serum shock.
This apparent specificity of the acquired fixed-tissue antianaphylatoxic insusceptibility, is in harmony with our conception that the hepatic anaphylatoxin is a specific secondary antigen, presumably of protein nature, conceivably a denaturization product of the primary protein used in sensitization or immunization.
Footnotes
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↵1 Work aided by a grant from the Committee on Scientific Research of the American Medical Association.
- Received March 14, 1927.
- Copyright © 1927 by The American Association of Immunologists, Inc.
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