Abstract
Ten monoclonal anti-DNA antibodies generated in three separate fusion experiments performed using nonimmunized B/W spleen cells were studied. Their antigenic specificities were demonstrated to be identical and directed against a conformational determinant of the B helical form of double-stranded DNA (dsDNA). These data suggest that autoantibodies to dsDNA in B/W mice could constitute a homogeneous population.
- Copyright © 1982 by American Association of Immunologists
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In this issue
Monoclonal anti-deoxyribonucleic antibodies. I. Isotype and specificity studies.
