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Regulation of human natural killing. I. The role of monocytes, interferon, and prostaglandins.

H S Koren, S J Anderson, D G Fischer, C S Copeland and P J Jensen
J Immunol November 1, 1981, 127 (5) 2007-2013;
H S Koren
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S J Anderson
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D G Fischer
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C S Copeland
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P J Jensen
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Abstract

We have found that human endogenous natural killer activity as measured in a rapid 51Cr release assay is unaffected by the presence of monocytes. Moreover, stimulation of natural killer cells by poly I:C is independent of monocytes. In contrast, the presence of monocytes in a mixed population of mononuclear cells that have been stimulated by poly I:C suppresses NK activity. The suppression is shown to be partially reversible if indomethacin (10(-6) M) is added to the cultures during stimulation. Culture supernatants of monocytes stimulated with poly I:C are shown to contain PGE1 in a radioimmunoassay, and have NK inhibitory activity comparable to that obtained with exogenous PGE1 added to NK assays at a concentration range of 10(-7) to 10(-9) M. Culture supernatants from poly I:C-stimulated monocytes do not have detectable levels of antiviral activity. In contrast, plastic nonadherent cells stimulated with poly I:C produce significant levels of interferon (100 to 200 U/ml/2 x 10(6) cells) but almost undetectable amounts of PGE. Supernatants of nonadherent cells incubated with indomethacin (10(-6) M) alone augment NK activity. Taken together, the results suggest that stimulation of mononuclear cells with poly I:C is dependent on and regulated by the relative levels of interferon produced by lymphocytes and PGE produced by monocytes.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 5
1 Nov 1981
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Regulation of human natural killing. I. The role of monocytes, interferon, and prostaglandins.
H S Koren, S J Anderson, D G Fischer, C S Copeland, P J Jensen
The Journal of Immunology November 1, 1981, 127 (5) 2007-2013;

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Regulation of human natural killing. I. The role of monocytes, interferon, and prostaglandins.
H S Koren, S J Anderson, D G Fischer, C S Copeland, P J Jensen
The Journal of Immunology November 1, 1981, 127 (5) 2007-2013;
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Print ISSN 0022-1767        Online ISSN 1550-6606