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Studies on natural killer (NK) cells. II. Serologic evidence for heterogeneity of murine NK cells.

R C Burton, S P Bartlett, V Kumar and H J Winn
J Immunol November 1, 1981, 127 (5) 1864-1868;
R C Burton
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S P Bartlett
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V Kumar
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H J Winn
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Abstract

NK cells are divided into 2 subclasses on the basis of cell surface antigens: NKA cells, which preferentially lyse lymphoma cells and which are readily destroyed by treatment with anti-H-2, rabbit anti-mouse, or anti-NK specific antibodies in the presence of C; and NKB cells, which preferentially lyse nonlymphoma tumor cells and which are resistant to anti-NK specific antibodies, partially sensitive to anti-H-2 specific antibodies, and only fully sensitive to rabbit anti-mouse serum and C. Thus, suspensions of spleen cells that were treated with anti-NK-1.2 antibodies and C lost virtually all lytic activity for 6 lymphoma cell lines, whereas lytic activity for 2 nonlymphoma cell lines remained largely intact. It must be noted, however, that unlike NK-1.2 expression, target cell preference is not an absolute indicator of NK cell subclass. Cytotoxic T cells were readily distinguished from NKA and NKB cells on the basis of their sensitivity to monoclonal anti-Thy-1.2 antibodies and resistance to anti-NK-1.2 antiserum and C.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 5
1 Nov 1981
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Studies on natural killer (NK) cells. II. Serologic evidence for heterogeneity of murine NK cells.
R C Burton, S P Bartlett, V Kumar, H J Winn
The Journal of Immunology November 1, 1981, 127 (5) 1864-1868;

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Studies on natural killer (NK) cells. II. Serologic evidence for heterogeneity of murine NK cells.
R C Burton, S P Bartlett, V Kumar, H J Winn
The Journal of Immunology November 1, 1981, 127 (5) 1864-1868;
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Print ISSN 0022-1767        Online ISSN 1550-6606