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Parallel cross-reactivity patterns of 2 sets of antigenically distinct cytochrome c peptides: possible evidence for a presentational model of Ir gene function.

D Hansburg, C Hannum, J K Inman, E Appella, E Margoliash and R H Schwartz
J Immunol November 1, 1981, 127 (5) 1844-1851;
D Hansburg
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C Hannum
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J K Inman
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E Appella
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E Margoliash
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R H Schwartz
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Abstract

B10.A mice were immunized with either the carboxyl terminal peptide fragment 81-104 of pigeon cytochrome c or its acetimidyl derivative and an immune response was seen with strong preference for the immunogen. Strain distribution studies and blocking with an anti-Ia monoclonal antibody indicated that the same immune response (Ir) gene and restriction element were utilized in both responses. The specificity of the responses were evaluated by restimulating in vitro with a set of cytochrome c fragments from various species. Even though the derivatized and native fragments were poorly cross-reactive, the same phylogenetic pattern was seen when pigeon cytochrome c fragment 81-104 primed cells were tested with the set of underivatized fragments and when acetimidyl pigeon cytochrome c fragment 81-104 primed cells were tested with the same set of derivatized fragments. Primed cells from a 2nd major histocompatibility complex congenic strain of mice, B10.A(5R), displayed equivalent discrimination between derivatized and native forms but showed a markedly different phylogenetic pattern of cross-reactivity. These data indicate that the immune system recognizes 2 sites on the nominal antigen. One site, which accounts for the common hierarchy and is under Ir gene control, contains residues Gln-100, and possibly other carboxyl terminal residues. The 2nd site, which effects the distinction between native and derivatized fragments, contains at least 1 lysine other than at the carboxyl terminal. The implications of these data for theories of T cell recognition and Ir gene function are discussed.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 5
1 Nov 1981
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Parallel cross-reactivity patterns of 2 sets of antigenically distinct cytochrome c peptides: possible evidence for a presentational model of Ir gene function.
D Hansburg, C Hannum, J K Inman, E Appella, E Margoliash, R H Schwartz
The Journal of Immunology November 1, 1981, 127 (5) 1844-1851;

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Parallel cross-reactivity patterns of 2 sets of antigenically distinct cytochrome c peptides: possible evidence for a presentational model of Ir gene function.
D Hansburg, C Hannum, J K Inman, E Appella, E Margoliash, R H Schwartz
The Journal of Immunology November 1, 1981, 127 (5) 1844-1851;
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Print ISSN 0022-1767        Online ISSN 1550-6606