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Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.

H Auchincloss Jr, K Ozato and D H Sachs
J Immunol November 1, 1981, 127 (5) 1839-1843;
H Auchincloss Jr
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K Ozato
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D H Sachs
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Abstract

Two separate monoclonal antibodies, 34-11-3S and 34-2-11S, produced by the fusion of C3H anti-BDF1 sensitized spleen cells to the SP2/0 myeloma variant cell line, were found to detect alloantigens on subpopulations of murine lymphocytes. Analysis of the strain specificities of these antibodies showed that both detected antigens determined by genes closely linked to the Ly-6 locus. However, analysis of the tissue distributions of antigen-bearing cells indicated that the 2 antibodies reacted with distinct antigens, only 1 of which was similar in distribution to the classically described Ly-6.2 antigen. Functional studies performed using cells treated with antibody plus C showed that these 2 antibodies defined lymphocyte subpopulations that are different from each other and from those defined by several other reported Ly-6-related antibodies. The data suggest that the Ly-6 locus consists either of multiple tightly linked genes exhibiting marked linkage disequilibrium or of a single gene, the protein product of which is subject to post-translational modifications during cell differentiation leading to the expression of new determinants.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 5
1 Nov 1981
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Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.
H Auchincloss, K Ozato, D H Sachs
The Journal of Immunology November 1, 1981, 127 (5) 1839-1843;

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Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.
H Auchincloss, K Ozato, D H Sachs
The Journal of Immunology November 1, 1981, 127 (5) 1839-1843;
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Print ISSN 0022-1767        Online ISSN 1550-6606