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T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.

W E Biddison, S O Sharrow and G M Shearer
J Immunol August 1, 1981, 127 (2) 487-491;
W E Biddison
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S O Sharrow
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G M Shearer
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Abstract

The requirement for specific T cell subsets in the in vitro generation of human influenza virus-immune cytotoxic T lymphocyte (CTL) responses was investigated. Peripheral blood T cell populations were identified by and selected for their reactivity with the monoclonal antibodies OKT3, OKT4, and OKT8. Influenza virus-immune CTL effectors are OKT3+, OKT4-, and OKT8+. Analysis of CTL precursors demonstrates that: 1) influenza-immune CTL precursors are OKT3+, OKT4-, and OKT8+; 2) CTL precursors require radioresistant OKT3+ helper T cells in order to generate strong cytotoxic responses; and 3) helper T cells can be obtained from either the OKT4+ or OKT4- populations, but more potent help was generated by the OKT4+ subset. The demonstration of a helper T cell requirement for the generation of influenza virus-immune CTL suggests that helper T cells may be involved in the previously documented HLA-linked Ir gene control of influenza-immune CTL responsiveness.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 2
1 Aug 1981
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T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.
W E Biddison, S O Sharrow, G M Shearer
The Journal of Immunology August 1, 1981, 127 (2) 487-491;

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T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help.
W E Biddison, S O Sharrow, G M Shearer
The Journal of Immunology August 1, 1981, 127 (2) 487-491;
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Print ISSN 0022-1767        Online ISSN 1550-6606