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I-Kk and H-2Kk antigens are shed as supramolecular particles in association with membrane lipids.

S G Emerson and R E Cone
J Immunol August 1, 1981, 127 (2) 482-486;
S G Emerson
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R E Cone
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Abstract

The form of 125I-labeled membrane alloantigens (I-Ak and H-2Kk) and immunoglobulin M shed by murine splenic lymphocytes labeled by lactoperoxidase-catalyzed radioiodination was determined by gel chromatography and ultracentrifugation. I-Ak and H-2Kk antigens are shed as particles ranging in size from 3 X 10(5) to 2 X 10(6), whereas membrane IgM is shed as an individual unit consonant with its native size of 180,000. The effects of detergents on the size of shed I-Ak and H-2Kk and the coprecipitation of (3H) lipids with these proteins suggest that I-Ak and H-2Kk are shed in association with local membrane lipids as small membrane-derived vesicles, whereas membrane IgM is shed without detectable associated lipid.

  • Copyright © 1981 by American Association of Immunologists

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The Journal of Immunology
Vol. 127, Issue 2
1 Aug 1981
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I-Kk and H-2Kk antigens are shed as supramolecular particles in association with membrane lipids.
S G Emerson, R E Cone
The Journal of Immunology August 1, 1981, 127 (2) 482-486;

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I-Kk and H-2Kk antigens are shed as supramolecular particles in association with membrane lipids.
S G Emerson, R E Cone
The Journal of Immunology August 1, 1981, 127 (2) 482-486;
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Print ISSN 0022-1767        Online ISSN 1550-6606