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Antigenic profile of murine natural killer cells.

G C Koo, J B Jacobson, G J Hammerling and U Hammerling
J Immunol September 1, 1980, 125 (3) 1003-1006;
G C Koo
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J B Jacobson
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G J Hammerling
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U Hammerling
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Abstract

We have determined the antigenic profile of natural killer (NK) cells from C57BL/6 mice that have lytic activity to RLmale1 tumor cells, in a 5-hr 51Cr release assay. To perform the antigenic typing more effectively, we enriched the NK populations by using discontinous BSA density gradient and established a correlation between NK activity and NK-1 antigen in each layer. As NK activity and Nk-1 antigen are both criteria for measuring NK cells, we determined the antigenic profile of NK cells by monitoring both the change in NK activity and NK-1 cells, after elimination of cells with various antisera to lymphocytic alloantigens. We have found that all NK cells expressed Nk-1, Qa-4, and Qa-5 antigens; about 50% of NK cells expressed Thy-1 and Qa-2 antigens, and 25% of NK cells also expressed Lyt-1 antigen. NK cells did not express significant amounts of Qa-1, Qa-3, Lyt-2, and Lyb-2 antigens. Therefore, spontaneous NK cells are heterogeneous with regard to their surface antigens, some of which are T cell antigens. However, the present antigenic profile does not allow us to classify NK cells in the conventional T cells lineage.

  • Copyright © 1980 by American Association of Immunologists

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The Journal of Immunology
Vol. 125, Issue 3
1 Sep 1980
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Antigenic profile of murine natural killer cells.
G C Koo, J B Jacobson, G J Hammerling, U Hammerling
The Journal of Immunology September 1, 1980, 125 (3) 1003-1006;

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Antigenic profile of murine natural killer cells.
G C Koo, J B Jacobson, G J Hammerling, U Hammerling
The Journal of Immunology September 1, 1980, 125 (3) 1003-1006;
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Print ISSN 0022-1767        Online ISSN 1550-6606