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A monoclonal antibody reactive with human peripheral blood monocytes.

J Breard, E L Reinherz, P C Kung, G Goldstein and S F Schlossman
J Immunol April 1, 1980, 124 (4) 1943-1948;
J Breard
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E L Reinherz
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P C Kung
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G Goldstein
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S F Schlossman
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Abstract

A monoclonal antibody directed at a determinant on human peripheral blood monocytes was produced and characterized. This hybridoma antibody, termed OKM1, was reactive by indirect immunofluorescence and complement- (C) mediated lysis with adherent mononuclear cells. OKM1 was unreactive with lymphocytes, thymocytes, lymphoblastoid cell lines, and tumor cells of the T or B cell lineage. In contrast, acute myelomonocytic leukemia cells and granulocytes were reactive with the antibody. Pretreatment of peripheral blood mononuclear cells with OKM1 and C before culture with soluble antigens totally abolished their antigen-induced proliferative response. This function was restored by addition of 1% adherent cells. These findings provided additional support for the notion that OKM1 was reactive with monocytes. In addition, OKM1 appeared to define two distinct populations of monocytes; an adherent population of large cells bearing surface Ia determinants and a nonadherent population of small, Ia-negative cells. These OKM1+ Ia- cells were found to be a contaminant of most fractionated mononuclear cell subsets including the E-SIg-Null cell population.

  • Copyright © 1980 by American Association of Immunologists

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The Journal of Immunology
Vol. 124, Issue 4
1 Apr 1980
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A monoclonal antibody reactive with human peripheral blood monocytes.
J Breard, E L Reinherz, P C Kung, G Goldstein, S F Schlossman
The Journal of Immunology April 1, 1980, 124 (4) 1943-1948;

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A monoclonal antibody reactive with human peripheral blood monocytes.
J Breard, E L Reinherz, P C Kung, G Goldstein, S F Schlossman
The Journal of Immunology April 1, 1980, 124 (4) 1943-1948;
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Print ISSN 0022-1767        Online ISSN 1550-6606