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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.

E L Reinherz, P C Kung, J M Breard, G Goldstein and S F Schlossman
J Immunol April 1, 1980, 124 (4) 1883-1887;
E L Reinherz
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P C Kung
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J M Breard
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G Goldstein
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S F Schlossman
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Abstract

Lymphocyte mitogenic factor functions as a nonspecific helper molecule generated from antigen stimulation of T lymphocytes. As such, it induces proliferation of all major lymphocyte subclasses (T, B, and Null cells) and B cell immunoglobulin synthesis. In the present study, the specific T cell subset requirements for LMF production were determined in man. By utilizing the OKT4 monoclonal antibody directed at the human inducer T cell subset, T lymphocytes were separated into OKT4+ and OKT4- subpopulations. The antigen stimulated OKT4+ subset generated LMF in a fashion comparable to the unfractionated T cell population and was itself capable of directly inducing B cell proliferation and antibody production. In contrast, LMF could not be generated from the OKT4-T cell subset although this population accounted for 40% of the unfractionated T cell population. In addition, the OKT4- subset was unable to facilitate B cell differentiation in the presence of soluble antigen. These studies provide the first report of T cell subset restriction for generation of helper factors in man and further stress the importance of the OKT4+ inducer population in regulation of the human immune response.

  • Copyright © 1980 by American Association of Immunologists

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The Journal of Immunology
Vol. 124, Issue 4
1 Apr 1980
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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.
E L Reinherz, P C Kung, J M Breard, G Goldstein, S F Schlossman
The Journal of Immunology April 1, 1980, 124 (4) 1883-1887;

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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.
E L Reinherz, P C Kung, J M Breard, G Goldstein, S F Schlossman
The Journal of Immunology April 1, 1980, 124 (4) 1883-1887;
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Print ISSN 0022-1767        Online ISSN 1550-6606