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The Qa-2 Antigen on Lymphocyte Subpopulations. Mixed Lymphocyte Culture and Cell-Mediated Lympholysis

Karen A. Sullivan and Lorraine Flaherty
J Immunol December 1, 1979, 123 (6) 2920-2924;
Karen A. Sullivan
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Lorraine Flaherty
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Abstract

Treatments of spleen cells from Qa-2+ strains with Qa-2 antiserum plus complement (C) have revealed that the Qa-2 antigen is present on restricted functional lymphocyte subpopulations. Anti-Qa-2 plus C reduced the mixed lymphocyte culture response and inhibited the generation of cytolytic effector cells. This treatment, however, did not affect cytolytic effector cells once they were generated.

Footnotes

  • ↵3 Reprint requests should be directed to Dr. Lorraine Flaherty, Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201.

  • ↵1 This work was supported in part by National Institutes of Health Research Grant No. AI 12603 awarded by the National Institute of Allergy and Infectious Diseases, Public Health Service, Department of Health, Education, and Welfare.

  • Received June 11, 1979.
  • Accepted September 18, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
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The Qa-2 Antigen on Lymphocyte Subpopulations. Mixed Lymphocyte Culture and Cell-Mediated Lympholysis
Karen A. Sullivan, Lorraine Flaherty
The Journal of Immunology December 1, 1979, 123 (6) 2920-2924;

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The Qa-2 Antigen on Lymphocyte Subpopulations. Mixed Lymphocyte Culture and Cell-Mediated Lympholysis
Karen A. Sullivan, Lorraine Flaherty
The Journal of Immunology December 1, 1979, 123 (6) 2920-2924;
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Print ISSN 0022-1767        Online ISSN 1550-6606