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Brucella Abortus Lipopolysaccharide Is Mitogenic for Spleen Cells of Endotoxin-Resistant C3H/HeJ Mice

Edgardo Moreno and David T. Berman
J Immunol December 1, 1979, 123 (6) 2915-2919;
Edgardo Moreno
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David T. Berman
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Abstract

Preparations of lipopolysaccharide (LPS) from rough and smooth strains of Brucella abortus were mitogenic for spleen cells of athymic nude mice, C3H/HeAU mice, and the endotoxin-resistant C3H/HeJ mice. The mitogenic response induced by crude smooth-LPS (f5) was greater than that produced by purified smooth-LPS (f5p); however, the dose-response curves were similar for both preparations. The mitogenic activity of mouse spleen cells to both f5 and f5p was higher than that produced by stimulation with purified rough-LPS. The dose-response curves with rough-LPS were also qualitatively different from those produced with the preparations of smooth-LPS.

Footnotes

  • ↵1 This work was supported by the College of Agricultural and Life Sciences, by cooperative Agreements with the United States Department of Agriculture, Animal and Plant Health Inspection Service, and the Science and Educational Administration, and by a grant from Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CON-ICIT) de Costa Rica.

  • Received July 2, 1979.
  • Accepted September 14, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
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Brucella Abortus Lipopolysaccharide Is Mitogenic for Spleen Cells of Endotoxin-Resistant C3H/HeJ Mice
Edgardo Moreno, David T. Berman
The Journal of Immunology December 1, 1979, 123 (6) 2915-2919;

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Brucella Abortus Lipopolysaccharide Is Mitogenic for Spleen Cells of Endotoxin-Resistant C3H/HeJ Mice
Edgardo Moreno, David T. Berman
The Journal of Immunology December 1, 1979, 123 (6) 2915-2919;
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Print ISSN 0022-1767        Online ISSN 1550-6606