Abstract
Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be “activated” and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.
Footnotes
- Received September 10, 1979.
- Accepted September 19, 1979.
- Copyright © 1979 by The American Association of Immunologists, Inc.
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