Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Monkeypox and Other Poxvirus Articles
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Monkeypox and Other Poxvirus Articles
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Defective Fc Receptor-Mediated Phagocytosis in C3H/HeJ Macrophages

I. Correction by Lymphokine-Induced Stimulation

Stefanie N. Vogel and David L. Rosenstreich
J Immunol December 1, 1979, 123 (6) 2842-2850;
Stefanie N. Vogel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David L. Rosenstreich
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Macrophages derived from LPS-unresponsive C3H/HeJ mice lose their ability to phagocytose opsonized SRBC (EA) after 24 hr of in vitro culture, whereas macrophages from normal mice exhibit a marked increase in phagocytosis of EA under the same culture conditions. Defective phagocytosis is not due to a decrease in macrophage number or viability and appears to be specific for Fc receptor-mediated phagocytosis, since phagocytosis of latex particles by C3H/HeJ macrophages is normal. The phagocytic defect appears to be due to a decrease in the binding ability or number of Fc receptors, since C3H/HeJ macrophages exhibit a loss of Fc binding ability that parallels the loss in their phagocytic ability. Cultured macrophages from LPS responsive (C3H/HeN) mice maintain their ability to bind EA after 48 hr culture.

This Fc receptor defect appears to be secondary to a failure of C3H/HeJ macrophages to maintain a differentiated state in vitro, since induction of differentiation of C3H/HeJ macrophages with the supernatant derived from Con A-treated spleen cells (CS) results in an almost complete restoration of both their ability to bind and phagocytose EA. The activity of CS appears to be due to a lymphokine, since it is not present in the culture supernatants of unstimulated spleen cells and is not produced by Con A alone.

These findings emphasize the close association between the induction of macrophage differentiation and the sensitivity of these cells to LPS. Furthermore, they suggest that one function of the Lps gene may be to regulate the ability of cells to respond to physiologic differentiation signals in addition to or instead of lipid A.

  • Received July 23, 1979.
  • Accepted September 12, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
  • Table of Contents
  • Table of Contents (PDF)
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Defective Fc Receptor-Mediated Phagocytosis in C3H/HeJ Macrophages
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Defective Fc Receptor-Mediated Phagocytosis in C3H/HeJ Macrophages
Stefanie N. Vogel, David L. Rosenstreich
The Journal of Immunology December 1, 1979, 123 (6) 2842-2850;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Defective Fc Receptor-Mediated Phagocytosis in C3H/HeJ Macrophages
Stefanie N. Vogel, David L. Rosenstreich
The Journal of Immunology December 1, 1979, 123 (6) 2842-2850;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Regulation of the Murine IgE Antibody Response
  • Role of Self Carriers in the Immune Response and Tolerance
  • Natural Killing in Estrogen-Treated Mice Responds Poorly to Poly I·C Despite Normal Stimulation of Circulating Interferon
Show more Cellular Immunology

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • FAR 889
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2022 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606