Abstract
The α and β subunits of the murine I-A alloantigens from several H-2 haplotypes were examined by comparative tryptic peptide mapping by using double label (3H and 14C) techniques. Significant structural variation between alleles was detected in both subunits. Tryptic digests of the α polypeptides from s, b, and d showed only 65% co-elution with k; β-chains from s, b, d, and r were about 50% similar to the k β subunit. Peptide analysis of the Ak subunits from intra-H-2 recombinant strains indicated that both the α and β polypeptides are encoded within the I-A subregion.
Footnotes
- Received July 3, 1979.
- Accepted September 12, 1979.
- Copyright © 1979 by The American Association of Immunologists, Inc.
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