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Experimental Malaria in the CBA/N Mouse

Anil N. Jayawardena, Charles A. Janeway Jr. and John D. Kemp
J Immunol December 1, 1979, 123 (6) 2532-2539;
Anil N. Jayawardena
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Charles A. Janeway Jr.
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John D. Kemp
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Abstract

CBA/N mice carry an X-linked, recessive gene, which results in the absence of a B cell subset, and is expressed primarily as an inability to respond to a certain class of thymus-independent antigens. We have examined the responses of these mice to the malaria parasite Plasmodium yoelii and found that primary infections induced by this parasite are more severe and last longer in mice with the X-linked defect than in normal controls. The decreased resistance of the defective mice is associated with a striking deficiency in their IgM antibody response. After recovery from a primary infection, defective mice resist reinfection with the homologous parasite as well as normal mice. Although as resistant as normal controls, B cells from defective mice transfer considerably less immunity to naive recipients than B cells from normal animals. Hence, two modes of thymus-dependent protective immunity may contribute to the host response to P. yoelii. Control of an acute primary infection appears to involve a thymus-dependent antibody response that CBA/N mice are deficient in. Resistance to reinfection may be mediated primarily by a different mechanism.

Footnotes

  • ↵2 Recipient of Research Career Development Award RF 78021 from the Rockefeller Foundation.

  • ↵3 Investigator, Howard Hughes Medical Institute.

  • ↵4 Supported by NIGMS Training Grant 54950.

  • ↵1 This work was supported by Grants AI-06112, AI-06455, AI-10497, AI-13766, and AI-13949 from the National Institutes of Health, Bethesda, Maryland.

  • Received July 2, 1979.
  • Accepted August 22, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
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Experimental Malaria in the CBA/N Mouse
Anil N. Jayawardena, Charles A. Janeway, John D. Kemp
The Journal of Immunology December 1, 1979, 123 (6) 2532-2539;

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Experimental Malaria in the CBA/N Mouse
Anil N. Jayawardena, Charles A. Janeway, John D. Kemp
The Journal of Immunology December 1, 1979, 123 (6) 2532-2539;
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Print ISSN 0022-1767        Online ISSN 1550-6606