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Idiotypic Analysis of Anti-GAT Antibodies

VI. Identification and Strain Distribution of the GA-1 Idiotype

Shyr-Te Ju, Michel Pierres, Ronald N. Germain, Baruj Benacerraf and Martin E. Dorf
J Immunol December 1, 1979, 123 (6) 2505-2510;
Shyr-Te Ju
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Michel Pierres
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Ronald N. Germain
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Baruj Benacerraf
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Martin E. Dorf
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Abstract

Previous studies demonstrated that anti-GAT antibodies of all inbred strains of mice share a common idiotype, termed CGAT idiotype. The CGAT idiotype is present on a major fraction of anti-GAT antibodies and is induced by the “GT”-related antigenic determinants on GAT molecules. The present paper describes another common idiotype of anti-GAT antibodies, termed GA-1 idiotype, the identification of which is based on a heterologous idiotypic interaction between guinea pig anti-idiotypic antiserum made against pooled specifically purified D1.LP anti-GAT antibodies and a monoclonal hybridoma anti-GAT antibody from the F9-102.2 cell line. The homologous anti-F9-102.2 idiotypic antiserum detected private idiotypic specificities.

GA-1 and CGAT are distinct idiotypes induced upon GAT immunization. Unlike CGAT idiotype, GA-1 idiotype is expressed on a minor fraction of the anti-GAT antibodies and “GA”-related antigenic determinants are responsible for the inducation of GA-1 idiotype. Thus, anti-GA, anti-GAT and anti-GLA40 antisera from 21 different inbred strains of mice expressed GA-1 idiotype. However, both the CE/J anti-GAT and anti-GA antisera lack detectable levels of GA-1 idiotype.

Footnotes

  • ↵1 This work was supported by Grants, AI-00152, and AI-14732 from the National Institutes of Health and Grant PCM-75-22422 from the National Science Foundation.

  • Received July 2, 1979.
  • Accepted August 17, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
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Idiotypic Analysis of Anti-GAT Antibodies
Shyr-Te Ju, Michel Pierres, Ronald N. Germain, Baruj Benacerraf, Martin E. Dorf
The Journal of Immunology December 1, 1979, 123 (6) 2505-2510;

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Idiotypic Analysis of Anti-GAT Antibodies
Shyr-Te Ju, Michel Pierres, Ronald N. Germain, Baruj Benacerraf, Martin E. Dorf
The Journal of Immunology December 1, 1979, 123 (6) 2505-2510;
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Print ISSN 0022-1767        Online ISSN 1550-6606