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Ecto-5′-Nucleotidase Activity in T and B Lymphocytes from Normal Subjects and Patients with Congenital X-Linked Agammaglobulinemia

Linda F. Thompson, Gerry R. Boss, Hans L. Spiegelberg, Inga V. Jansen, Richard D. O'Connor, Thomas A. Waldmann, Robert N. Hamburger and J. Edwin Seegmiller
J Immunol December 1, 1979, 123 (6) 2475-2478;
Linda F. Thompson
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Gerry R. Boss
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Hans L. Spiegelberg
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Inga V. Jansen
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Richard D. O'Connor
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Thomas A. Waldmann
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Robert N. Hamburger
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J. Edwin Seegmiller
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Abstract

Ecto-5′-nucleotidase activity was measured in lymphocyte subpopulations isolated from normal subjects and patients with congenital X-linked agammaglobulinemia. B lymphocytes from normal subjects have at least three times more ecto-5′-nucleotidase activity than T lymphocytes. Patients with X-linked agammaglobulinemia have 56% of normal activity in their T cells, and lack a lymphocyte subpopulation high in nucleotidase activity. High activity of ecto-5′-nucleotidase may be a biochemical marker for mature surface immunoglobulin-bearing B cells.

Footnotes

  • ↵2 L. Thompson was supported by a post-doctoral fellowship from the Arthritis Foundation.

  • ↵3 To whom reprints should be sent.

  • ↵1 This work was supported in part by National Institutes of Health Grants GM17702, AM13622, and AI-10734(HLS).

  • Received June 12, 1979.
  • Accepted August 17, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 6
1 Dec 1979
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Ecto-5′-Nucleotidase Activity in T and B Lymphocytes from Normal Subjects and Patients with Congenital X-Linked Agammaglobulinemia
Linda F. Thompson, Gerry R. Boss, Hans L. Spiegelberg, Inga V. Jansen, Richard D. O'Connor, Thomas A. Waldmann, Robert N. Hamburger, J. Edwin Seegmiller
The Journal of Immunology December 1, 1979, 123 (6) 2475-2478;

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Ecto-5′-Nucleotidase Activity in T and B Lymphocytes from Normal Subjects and Patients with Congenital X-Linked Agammaglobulinemia
Linda F. Thompson, Gerry R. Boss, Hans L. Spiegelberg, Inga V. Jansen, Richard D. O'Connor, Thomas A. Waldmann, Robert N. Hamburger, J. Edwin Seegmiller
The Journal of Immunology December 1, 1979, 123 (6) 2475-2478;
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Print ISSN 0022-1767        Online ISSN 1550-6606