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Presence of T Cell-Associated Surface Antigens on Murine NK Cells

Sylvia B. Pollack, Milton R. Tam, Robert C. Nowinski and Sandra L. Emmons
J Immunol October 1, 1979, 123 (4) 1818-1821;
Sylvia B. Pollack
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Milton R. Tam
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Robert C. Nowinski
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Sandra L. Emmons
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Abstract

The expression of T cell-associated surface antigens on natural killer (NK) spleen cells of C57BL/6 mice was evaluated by cytotoxic depletion experiments with alloantisera prepared against the Thy 1, Ly 1, Ly 2, Ly 5, Ly 6, and NK 1 antigens. The NK activity of these nonimmunized spleen cells for YAC-1 leukemia cells was dramatically reduced by antisera to the Ly 5 and NK 1 antigens. Variable results were obtained with anti-Ly 6 sera—certain pools of this antiserum decreased the NK activity, whereas other pools showed only negligible effects. The NK activity of the same cell suspensions was not affected by antisera to the Thy 1, Ly 1, and Ly 2 antigens. In parallel tests the T cell-associated cell surface antigens of alloimmune T killer cells were similarly evaluated by cytotoxic depletion experiments. In this case, the activity of these cells was consistently diminished by antisera to the Thy 1, Ly 2, Ly 5, and Ly 6 antigens, but not by antisera to the Ly 1 and NK 1 antigens. On this basis it was concluded that the NK cells expressed a restricted subset of T cell-associated alloantigens and therefore may have been derived from the T cell lineage of lymphocytes.

Footnotes

  • ↵2 Please address correspondence to Dr. Pollack, Tumor Immunology, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Wash. 98104.

  • ↵1 This work was supported by Grants CA 18647 and CA 18074 from the National Institutes of Health.

  • Received April 16, 1979.
  • Accepted July 16, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 4
1 Oct 1979
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Presence of T Cell-Associated Surface Antigens on Murine NK Cells
Sylvia B. Pollack, Milton R. Tam, Robert C. Nowinski, Sandra L. Emmons
The Journal of Immunology October 1, 1979, 123 (4) 1818-1821;

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Presence of T Cell-Associated Surface Antigens on Murine NK Cells
Sylvia B. Pollack, Milton R. Tam, Robert C. Nowinski, Sandra L. Emmons
The Journal of Immunology October 1, 1979, 123 (4) 1818-1821;
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Print ISSN 0022-1767        Online ISSN 1550-6606