Abstract
An in vitro cytotoxic cell response against alloantigens was inhibited by antibody directed against the alloantigens and also by anti-trinitrophenyl antibody provided that the allogeneic stimulator cells were modified with trinitrophenyl. Inhibition of an anti-allogeneic cytotoxic cell response against trinitrophenyl-coupled allogeneic stimulator cells by anti-trinitrophenyl antibody is dependent upon the intact Fc portion of inhibitory antibody. The magnitude of the difference between intact and F(ab′)2 anti-trinitrophenyl antibody in immunosuppressive activity suggests that the Fc portion emits negative signals rather than simply adding to a steric hindrance effect.
Footnotes
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↵1 This work was supported by grants from The National Cancer Institute and The Medical Research Council of Canada.
- Received May 8, 1979.
- Accepted June 22, 1979.
- Copyright © 1979 by The American Association of Immunologists, Inc.
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